FUNDED PROJECTS:
MENTAL DISEASES

cartell MaratóThe 2000 Marathon, dedicated to serious mental diseases, distributed € 4,118,520 among 53 biomedical research projects. The results were published in the VII Simposium Fundació La Marató de TV3, which took place in 2006.
Below is a list of the projects financed by La Marató in 2000. Those that led to the production of scientific literature are underlined.

Pharmacogenomics of the treatment of serious mental diseases

  • Dr. Enric Álvarez Martínez
    Hospital de la Santa Creu i Sant Pau
Fund: 109.085 €

Dopamine toxicity mechanisms in cell models. Molecular approach to the role of dopamine in psychiatric pathology

  • Santiago Ambrosio Viale
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 46.655 €

Overexpression and haploinsufficiency of Dyrk1A (minibrain) in mental retardation and of attention deficit/hyperactivity

  • Dra. M. Lourdes Arbonés de Rafael
    Centre de Genètica Mèdica i Molecular. IRO
  • Dr. Javier Felipe Oroquieta
    Instituto Cajal. CSIC
Fund: 93.375 €

Characterisation and identification of components of the transport machinery o the cell surface of NMDA glutamate

  • Dr. Joaquín V. Arribas López
    Hospitals Vall d'Hebron
Fund: 101.198 €

5-HT1A receptors in the prefrontal cortex and the raphe nuclei: relevance in the physiopathology and treatment of major depressive disorder

  • Dr. Francesc Artigas Pérez
    Institut d'Investigacions Biomèdiques de Barcelona
  • Dr. Víctor Pérez Sola
    Hospital de la Santa Creu i Sant Pau
  • Dra. Montserrat Estorch Cabrera
    Hospital de la Santa Creu i Sant Pau
Fund: 150.602 €

EEG changes after single oral administration of neuroleptics in schizophrenia: evaluation of the characteristics as a response predictor using an alternative strategy with family members and integrating plasma and neuroleptic levels

  • Dr. Manuel-José Barbanoj Rodríguez
    Hospital de la Santa Creu i Sant Pau
Fund: 110.122 €

Multidisciplinary study of the utility of plasmatic homovanillic acid determination as a relapse predictor in schizophrenic patients

  • Dr. Miquel Bernardo Arroyo
    Hospital Clínic i Provincial de Barcelona
Fund: 68.307 €

Efficacy of neuropsychological rehabilitation in chronic schizophrenia: repercussions on the clinical variables, cerebral activity and psychosocial functioning

  • Dra. Teresa Boget Llucià
    Hospital Clínic i Provincial de Barcelona
Fund: 54.452 €

Abuse substances as a risk factor in schizophrenia

  • Dr. Jordi Camarasa Garcia
    Facultat de Farmàcia. Universitat de Barcelona
Fund: 56.863 €

Polymorphisms TaqIA, TaqIB and 141C Del/Ins in gene D2 of the dopamine receptor and likelihood of suffering extrapyrimidal effects induced by antipsychotics in patients with schizophrenia

  • Dr. Xavier Carné Cladellas
    Hospital Clínic i Provincial de Barcelona
Fund: 43.075 €

Extrapyrimidal reactions as a side-effect of treatment with antipsychotics: role of the mitochondrial respiratory chain

  • Dr. Jordi Casademont Pou
    Hospital Clínic i Provincial de Barcelona
Fund: 55.195 €

Prenatal endotoxic shock in the rat: experimental model of schizophrenia with possible heuristic value

  • Dr. Bernardo Castellano López
    Facultat de Medicina. Universitat Autònoma de Barcelona
  • Dr. José Borrell Andres
    Instituto Cajal. CSIC
Fund: 126.040 €

Association between nutritional status, free homovanillic acid, and psychopathology in anorexia nervosa and bulimia nervosa

  • Dra. Josefina Castro Fornieles
    Hospital Clínic i Provincial de Barcelona
Fund: 21.377 €

Image of cerebral neurotransmission in vivo using SPECT: methodological innovations with implications in research and the development of new therapeutic strategies in schizophrenia and in depression

  • Dra. Ana M. Catafau Alcántara
    Hospital de la Santa Creu i Sant Pau
Fund: 96.324 €

Neuropsychological functioning, minor neurological signs and neurodevelopment markers as determinants of needs, response to treatment and evolution in people with schizophrenia: a 5-year follow-up study

  • Dr. Jorge A. Cervilla Ballesteros
    Sant Joan de Déu Serveis de Salut Mental
Fund: 90.010 €

Murine models of overexpression of subunits A3 (CHRNA3), A5 (CNFA5) and B4 (CHRNB4), of the nicotine receptors contained in genome mutation DUP25, implicated in panic attack disorder and phobic disorders

  • Dra. Mara Dierssen Sotos
    Centre de Genètica Mèdica i Molecular. IRO
Fund: 87.147 €

Neurotrophic and neurotoxic effects of lithium

  • Dr. Josep Enric Esquerda Colell
    Facultat de Medicina. Universitat de Lleida
  • Dra. María Jesús Luna Ibarz
    Hospital de Santa Maria. Lleida
Fund: 46.445 €

Causes and consequences of genome mutation DUP25 as a genetic susceptibility factor for serious mental disorders: panic-phobia disorder

  • Dr. Xavier Estivill Pallejà
    Centre de Genètica Mèdica i Molecular. IRO
  • Dra. Rocío Martín-Santos Laffon
    Hospital del Mar
Fund: 76.755 €

Identification of risk genotypes for schizophrenia and other psychoses: psychopathological redefinition of the phenotypes and approach to current aetiopathogenic models

  • Dra. Lourdes Fañanás Saura
    Facultat de Biologia. Universitat de Barcelona
  • Dra. Rosa Miró Ametller
    Facultat de Medicina. Universitat Autònoma de Barcelona
Fund: 123.301 €

Neuroevolutive model of schizophrenia, for preclinical evaluation of antipsychotic pharmaceutical products

  • Dra. Núria Ferré Suana
    Facultat de Psicologia. Universitat Autònoma de Barcelona
Fund: 37.798 €

Molecular and functional interaction of dopamine and adenosine receptors and their involvement in the neurological alterations associated with schizophrenia

  • Dr. Rafael Franco Fernández
    Facultat de Química. Universitat de Barcelona
Fund: 108.253 €

Major depression and quality of life: evolution in a cohort of puerperal women

  • Dra. Lluïsa Garcia Esteve
    Institut Clínic de Psiquiatria i Psicologia
Fund: 34.740 €

Vulnerability to mental disorder in offspring of parents who suffer severe mental disorder (SMD)

  • Dr. Andrés García Siso
    Hospital Universitari Institut Pere Mata. Reus
Fund: 11.476 €

Low and high-frequency combined repetitive transcranial magnetic stimulation in resistant major depression

  • Dr. Mauro García Toro
    Hospital Psiquiàtric de Mallorca
Fund: 40.963 €

NMR studies of prolyl endopeptidase. Application and design of inhibitors

  • Dr. Ernest Giralt Lledó
    Facultat de Química. Universitat de Barcelona
Fund: 99.516 €

Evaluation of a family intervention technique in schizophrenia

  • Dr. Manuel Girón Giménez
    Facultat de Medicina. Universitat Miguel Hernández. Alacant
Fund: 39.760 €

Factors associated with eating disorders: study of control cases

  • Dra. Maria Pilar Gual Garcia
    Facultat de Ciències de la Salut. Universitat Internacional de Catalunya
  • Dra. Araceli Gila Castro
    Hospital Clínic i Provincial de Barcelona
  • Dr. Salvador Cervera Enguix
    Clínica Universitaria de Navarra
Fund: 93.073 €

The lipid hypothesis of schizophrenia: a new therapeutic approach. Calcium-independent phospholipase A2 inhibitors: synthesis, enzyme inhibition and signal transduction

  • Dr. Diego Haro Bautista
    Facultat de Farmàcia. Universitat de Barcelona
  • Dr. Amadeu Llebaria Soldevila
    Institut d'Investigacions Químiques i Ambientals. CSIC
  • Dr. Jesús Balsinde Rodriguez
    Instituto de Biologia y Genética Molecular. CSIC
Fund: 240.405 €

Study for the detection of schizotaxic phenotypes in schizophrenic patients and their first-degree family members. Relationship with other psychotic disorders

  • Dr. Antonio Labad Alquézar
    Hospital Universitari Institut Pere Mata. Reus
Fund: 72.363 €

Structural, metabolic and functional cerebral alterations of obsessive-compulsive disorder in children and adolescents, evaluated by magnetic resonance (volumetric, spectroscopic and functional). Changes in the function of the therapeutic response

  • Dra. Luisa Lázaro García
    Hospital Clínic i Provincial de Barcelona
Fund: 25.254 €

Evaluation of the effectiveness of home nursing cures administered to patients suffering from SMD by the application of a case-management-based intervention model

  • Dra. M. Teresa Lluch Canut
    Escola Universitària d'Infermeria. Universitat de Barcelona
Fund: 31.553 €

Usefulness of the SPECT of dopaminergic presynapse with (123I) FP-CIT (DaTSCAN), as a predictor of the appearance of Parkinson's induced by antipsychotics in schizophrenic patients

  • Dr. Francisco Juan Lomeña Caballero
    Hospital Clínic i Provincial de Barcelona
Fund: 59.500 €

Fine-tuning of behavioural, neurochemical, and molecular models and their application in the development of new antipsychotic therapies

  • Dr. Rafael Maldonado López
    Facultat de Ciències de la Salut i de la Vida. Universitat Pompeu Fabra
  • Dr. Emilio Fernández Espejo
    Facultad de Medicina. Universidad de Sevilla
  • Dr. Ferran Sanz Carreras
    Institut Municipal d'Investigació Mèdica
  • Dra. María Isabel Loza García
    Facultad de Farmacia. Universidad de Santiago de Compostela
Fund: 240.405 €

Specific neuropsychological factors in senile depression for the prognostic study of the disease: executive functions and SPECT

  • Dr. Teodor Marcos Bars
    Hospital Clínic i Provincial de Barcelona
Fund: 39.358 €

Involvement of inflammatory mechanisms in chronic treatment with neuroleptics: an in vivo and in vitro study

  • Dra. Concepció Marin Agustin
    Hospital Clínic i Provincial de Barcelona
Fund: 82.306 €

Study of the apolipoprotein E (APOE) genes and of the alpha (ESR1) and beta (ESR2) oestrogen receptors in relation to the different expression of schizophrenia in men and women

  • Dra. Lourdes Martorell Bonet
    Hospital Universitari Institut Pere Mata. Reus
Fund: 62.753 €

Aetiopathogeny of the obsessive-compulsive disorder: genetic, neurophysiological, neuropsychological and structural neuroimage study

  • Dr. Josep Manuel Menchón Magriñà
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 106.209 €

Study of the alteration of the signal transduction mechanisms in the prefrontal cortex in schizophrenics with different pharmacological treatments

  • Dra. Guadalupe Mengod Los Arcos
    Institut d'Investigacions Biomèdiques de Barcelona
  • Dr. Francesc Pérez Arnau
    Sant Joan de Déu Serveis de Salut Mental
Fund: 108.434 €

AutismeAutism: study and classification of patients in the autistic spectrum and involvement of the MECP2 (Xq28) gene and of functional candidate genes of the 15q11-q13 regions in autism associated with mental retardation

  • Dra. Eugenia Monrós Marín / Dr. Rafael Artuch
    Hospital Universitari Sant Joan de Déu
Fund: 100.297 €

Comparative study of the incidence and evolution of the first outbreaks of psychotic disorders among the immigrant and native population of Andorra

  • Dr. Joan Obiols Llandrich
    Servei Andorrà d'Atenció Sanitària
Fund: 20.699 €

Psychoeducation and early detection programme of childhood-onset psychotic disorders

  • Dr. Jordi Obiols Llandrich
    Facultat de Psicologia. Universitat Autònoma de Barcelona
Fund: 25.046 €

Functional neuroanatomy of auditory hallucinations in schizophrenia: multidisciplinary study with PET-F18-FDG in the acute psychotic episode, during remission and during acoustic stimulation

  • Dr. Eduard Parellada Rodón
    Hospital Clínic i Provincial de Barcelona
Fund: 70.946 €

Clinical, neurochemical, and neuroimage factors associated with response to treatment with atypical antipsychotics and with the prediction of relapse in patients with a first schizophrenic episode

  • Dr. Lluís San Molina
    Benito Menni Complex Assistencial en Salut Mental
  • Dr. Ignasi Carrió Gasset
    Hospital de la Santa Creu i Sant Pau
Fund: 123.625 €

Omega-3-type fatty acids and bipolar disorder

  • Dr. Ramón Segura Cardona
    Facultat de Medicina. Universitat de Barcelona
Fund: 83.729 €

Role of the reelin signalling pathway in the pathogenesis of schizophrenia

  • Dr. Eduardo Soriano Garcia
    Facultat de Biologia. Universitat de Barcelona
  • Dr. Héctor Juan Caruncho Michinel
    Facultad de Biologia. Universidad de Santiago de Compostela
Fund: 124.945 €

Study of the LERN1 axon guidance gene and its function in relation to panic and anxiety attack syndrome

  • Dr. Lauro Sumoy Van Duck
    Centre de Genètica Mèdica i Molecular. IRO
Fund: 84.196 €

Risk factors for suffering psychotic disorder. Design of a detection instrument applicable in childhood and adolescence

  • Dr. Jorge Tizón García
    Unitat de Salut Mental Sant Martí Nord. ICS
Fund: 58.995 €

A psychogenetic model of vulnerability to psychoses: attention filtration, dopaminergic sensitisation and molecular markers of neuronal activity in Roman RHA rats

  • Dr. Adolf Tobeña Pallarés
    Facultat de Medicina. Universitat Autònoma de Barcelona
Fund: 81.004 €

Pharmacogenomic study of patients with severe mental disorder: opiate addicts who do not respond to methadone maintenance treatment

  • Dra. Marta Torrens Mèlich
    Hospital del Mar
Fund: 79.045 €

The psychopathic personality in adolescents: evaluation, cognitive processes, emotion and behaviour

  • Dr. Rafael Torrubia Beltri
    Facultat de Medicina. Universitat Autònoma de Barcelona
Fund: 45.473 €

Study of the efficacy of a computerised neuropsychological rehabilitation programme in patients with schizophrenia

  • Dr. Josep M. Vendrell Brucet
    Hospital de Terrassa
Fund: 71.935 €

Evaluation of a programme designed for home nursing care

  • Dr. Enric Vicens Pons
    Sant Joan de Déu Serveis de Salut Mental
Fund: 23.932 €

Risk factors of poor compliance with pharmacological treatment and bad evolution in bipolar disorder

  • Dr. Eduard Vieta Pascual
    Hospital Clínic i Provincial de Barcelona
Fund: 34.206 €
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