FUNDED PROJECTS:
NEURODEGENERATIVE DISEASES

cartell MaratóIn the 2013 Marató, which dealt with neurodegenerative diseases, 187 projects were presented and these were assessed by 96 scientists specialising in these diseases, according to their quality, methodology and relevance. This assessment was managed by the Agency for Health Quality and Assessment of Catalonia, of the Catalan Ministry of Health.
In accordance with the proposal of the scientific Advisory Committee of the Fundació La Marató de TV3, the Board agreed to distribute € 11,220,828.94 to the following 44 research projects of excellence:

Modulation of synaptic plasticity deficit as a therapeutic strategy in Huntington disease

  • Dr. Jordi Alberch Vié
    Facultat de Medicina. Universitat de Barcelona
  • Dra. Isabel Pérez Otaño
    Institut de Neurociències. Universitat Miguel Hernández. Alacant
Fund: 299.375 €

Function of the phosphorylation of the NMDA receptors in the aetiopathology of Alzheimer disease: from proteomics to in vivo models

  • Dr. Xavier Altafaj Tardio
    IDIBELL - Institut d'Investigació Biomèdica de Bellvitge. L'Hospitalet de Llobregat
Fund: 199.715,36 €

Rational screening programme for stabilising compounds of the transthyretin-Aß binding as potential modulating drugs of Alzheimer disease

  • Dra. Gemma Arsequell Ruiz
    Institut Química Avançada de Catalunya - CSIC. Barcelona
  • Dra. Isabel Cardoso
    Institute for Molecular Biology and Cell Biology. Porto
  • Dr. Jordi Llop Roig
    Asociación Centro de Investigación Coop. Biomateriales - CICbiomaGUNE. San Sebastian
  • Dr. Jesús Jiménez Barbero
    CIC bioGUNE. Center for Cooperative Research in Biosciences
  • Dr. Jordi Ramon Quintana Ruiz
    Parc Científic de Barcelona - UB. Barcelona
Fund: 399.550 €

Blocking in Parkinson’s disease: improving quality of life with an automatic control system

  • Dra. Àngels Bayés Rusiñol
    Centro Médico Teknon. Barcelona
  • Dr. Andreu Català Mallofre
    Centre Estudis Tecnològics Dependència i Vida Autònoma - UPC. Vilanova i la Geltrú
  • Dr. Rui Sarmento e Castro
    Fraunhofer AICOS - Associaçao Fraunhofer Portugal Research- Porto
Fund: 300.000 €

Identification of specific biological signatures from plasma samples for differential diagnosis of dementia with Lewy bodies

  • Dra. Katrin Beyer
    Hospital Universitari Germans Trias i Pujol - FIIGTiP
Fund: 198.184,68 €

Validation of the heteromers between neuronal dopamine D1 and histamine H3 receptors as a new treatment for Huntington’s disease

  • Dr. Enric I. Canela Campos
    Facultat de Biologia. Universitat de Barcelona
Fund: 200.000 €

Characterisation and validation of a new oligomer of the ß-amyloid protein as a pharmacological target for the treatment of Alzheimer’s disease

  • Dra. Natàlia Carulla Casanova
    IRB - Institut Recerca Biomèdica de Barcelona
  • Dr. Serge Muyldermans
    Structural Biolgy Research Center - VIB. Brussel·les (Bèlgica)
  • Dr. Giovanni Maglia
    University of Leuven (Bèlgica)
Fund: 332.492 €

Systems biomedicine to find the molecular bases and the model of corticospinal motor neuron disease

  • Dr. Carlos Casasnovas Pons
    IDIBELL - Institut d'Investigació Biomèdica de Bellvitge. L'Hospitalet de Llobregat
  • Dra. Maria Jesús Sobrido Gomez
    FP Galega de Medicina Xenómica - Fundación Ramon Domínguez. Santiago de Compostela
  • Dra. Cristina Pujades Corbi
    Parc de Recerca Biomèdica de Barcelona - UPF. Barcelona
  • Dra. Mariona Jové Font
    IRBLL Institut Recerca Biomèdica de Lleida - Fundació Dr. Pifarré
Fund: 399.995,53 €

Cholesterol and mitochondrial oxidative stress induced by Aß as causation factors and therapeutic targets in Alzheimer’s disease

  • Dra. Anna Colell Riera
    Institut Investigacions Biomèdiques de BCN - CSIC. Barcelona
  • Dr. Tobias Hartmann
    Deutsches Institut für Demenzprävention DID - Saarland University. Hamburg
Fund: 281.735 €

Bilingualism as a cognitive reserve factor in normal and pathological ageing

  • Dr. Albert Costa Martínez (RIP)
    Centre del Cervell i Cognició - UPF. Barcelona
  • Dr. César Avila River
    Facultat de Ciències de la Salut - Universitat Jaume I. Castelló de la Plana
Fund: 295.136,25 €

proNGF/p75NTR signalling in adult hippocampal neurogenesis: potential target for generation of new neurons in Alzheimer’s disease

  • Dra. Carme Espinet Mestre
    IRBLL Institut Recerca Biomèdica de Lleida - Universitat de Lleida
Fund: 200.000 €

Alzheimer’s disease in Down syndrome. Multimodal studies with LCR, RM, EEG and PET

  • Dr. Juan Fortea Ormaechea
    Hospital de la Santa Creu i Sant Pau - IRHSP Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Fund: 199.000 €

Cannabinoid receptor heteromers as therapeutic targets in Parkinson’s disease

  • Dr. Rafael Franco Fernández
    Facultat de Biologia – Universitat de Barcelona
  • Dr. José Luis Lanciego Pérez
    Centro de Investigación Médica Aplicada - FIMANavarra. Pamplona
Fund: 299.056,25 €

Deciphering the relationship between astrocyte reactivity and neuronal damage in Alzheimer’s disease

  • Dra. Elena Galea Rodriguez de Velasco
    Institut de Neurociències – Universitat Autònoma de Barcelona
  • Dr. Javier Vitorica Ferrandez
    Facultad de Farmacia - Universidad de Sevilla
  • Dra. Antonia Gutiérrez Perez
    Facultad de Ciencias - Universidad de Málaga
  • Dr. Joan Xavier Comella Carnicé
    VHIR - Institut de Recerca Hospital Universitari Vall d'Hebron
Fund: 382.250,90 €

Cognitive training based on digital memories due to mild cognitive impairment (rememory)

  • Dra. Maite Garolera Freixa
    Hospital de Terrassa - Consorci Sanitari de Terrassa
Fund: 195.485,71 €

Prevalence of Alzheimer type pathology in non-Alzheimer neurodegenerative diseases and its implication for the development of biomarkers: post mortem study based on a neurological tissue bank

  • Dra. Ellen Gelpi Mantius
    IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
Fund: 198.815 €

Analysis of protein traffic in retinal neurodegeneration using high-resolution microscopy in animal models and hiPSC

  • Dra. Roser Gonzalez Duarte
    Facultat de Biologia. Universitat de Barcelona
  • Dr. Pablo Loza Álvarez
    ICFO - Institut de Ciències Fotòniques. Castelldefels
  • Dr. Slaven Erceg
    Fundación Pública Andaluza Progreso y Salud - CABIMER. Sevilla
Fund: 400.000 €

Diagnostic and prognostic biomarkers in paediatric multiple sclerosis and related demyelinising diseases

  • Dr. Albert Saiz Hinarejos
    Hospital Clínic i Provincial de Barcelona. Fundació Clínic per a la Recerca Biomèdica
  • Dra. Mar Tintoré Subirana
    VHIR - Institut de Recerca Hospital Universitari Vall d'Hebron
Fund: 300.000 €

Therapeutic effect of conjugated liposomes in recombinant ApoJ/Clusterin protein in experimental models of Alzheimer’s disease

  • Dra. Mar Hernández-Guillamon
    VHIR - Institut de Recerca Hospital Universitari Vall d'Hebron
Fund: 200.000 €

Molecular image of the retina in patients with multiple sclerosis by means of Raman spectroscopy

  • Dra. Elena Hernández Martínez de Lapiscina
    IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
  • Dr. Pablo Loza Álvarez
    ICFO - Institut de Ciències Fotòniques. Castelldefels
Fund: 300.000 €

Identification of reliable sources of retina stem cells for cell replacement therapy in retina degeneration diseases

  • Dra. Eloisa Herrera
    Institut de Neurociències d'Alacant - CSIC. Sant Joan d'Alacant
  • Dra. Marta Agudo Barriuso
    Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca - Fundación para la Formación e Investigación Sanitaria
Fund: 233.261,25 €

Importance of IL-6 trans-signalling in a mouse model of Alzheimer’s disease

  • Dr. Juan Hidalgo Pareja
    Facultat de Biociències. Universitat Autònoma de Barcelona
Fund: 183.271,25 €

Changes in cerebral connectivity throughout the degenerative process of Parkinson’s disease

  • Dra. Carme Junqué Plaja
    IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
Fund: 161.148,75 €

Predictors of apathy and impulse control disorders in Parkinson’s disease based on feedback-related negativity

  • Dr. Jaume Kulisevsky Bojarski
    Institut Recerca Hospital de l'Hospital de la Santa Creu i Sant Pau
Fund: 199.607,50 €

New technologies applicable to clinical practice for obtaining biomarkers of atrophy and lesions in magnetic resonance images of patients with multiple sclerosis (BiomarkEm.cat)

  • Dr. Xavier Lladó Bardera
    Escola Politècnica Superior - Universitat de Girona
  • Dr. Jordi Rio Izquierdo
    Centre d'Esclerosi Múltiple de Catalunya CEMCAT - Institut de Recerca de la Vall d'Hebron
  • Dr. Joan Carles Vilanova Busquets
    Institut Hospital Dr. Josep Trueta Girona - IDIBGI
Fund: 399.969,26 €

Synaptic markers in preclinical Alzheimer’s disease

  • Dr. Alberto Lleó Bisa
    Hospital de la Santa Creu i Sant Pau - Institut de Recerca HSCiSP
Fund: 199.878,75 €

Catalan Multisystem Atrophy Network: biomarkers and pathophysiology

  • Dra. Josefa Maria Martí Domènech
    IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
  • Dr. Gian Gaetano Tartaglia
    Centre de Regulació Genòmica
Fund: 299.611,25 €

Gene therapy directed at neuregulins for treatment of amyotrophic lateral sclerosis

  • Dr. Xavier Navarro Acebes
    Facultat de Medicina - Universitat Autònoma de Barcelona
Fund: 199.682,50 €

Blood and neurophysiological markers of the progression of cognitive impairment in Parkinson’s disease

  • Dr. Javier Pagonabarraga Mora
    Hospital de la Santa Creu i Sant Pau - Institut de Recerca HSCiSP
Fund: 199.486,25 €

Adaptation and normalisation of neuropsychological instruments to the Catalan language

  • Dr. Jordi Peña Casanova
    IMIM - Institut Hospital del Mar d'Investigacions Mèdiques
Fund: 150.250 €

Neurodegeneration with brain iron accumulation: clinical evaluation and genetic characterisation through a Spanish multicentre research network

  • Dra. Belén Pérez Dueñas
    VHIR Institut de Recerca Hospital Universitari Vall d'Hebron
  • Dra. Espinós-Armero
    Centro de Investigación Príncipe Felipe - CIBERER. València
Fund: 284.123,75 €

Impact of obstructive sleep apnoea on the progression of Alzheimer’s disease. Role of hypoxia sleep fragmentation

  • Dr. Gerard Piñol Ripoll
    Hospital de Santa Maria - Institut de Recerca Biomèdica Fundació Dr. Pifarré Lleida
  • Dr. Ramon Farré Ventura
    Facultat de Medicina. Universitat de Barcelona
  • Dr. David Gozzal
    University of Chicago Medical Center
Fund: 386.100 €

Role of reelin in the splicing of the molecular mechanisms of Alzheimer’s disease: tauopathy, amyloid toxicity and transmissibility

  • Dr. Lluis Pujadas Puigdomènech
    VHIR - Institut de Recerca Hospital Universitari Vall d'Hebron
  • Dr. José María Delgado García
    Facultad de Ciencias Experimentales - Universidad Pablo de Olavide. Sevilla
Fund: 299.943 €

Role of PrPc as a cross-talk protein between alpha-synuclein/LRRK2 and p-Tau in sporadic and/or familial Parkinson’s diseaser

  • Dr. José Antonio del Rio Fernández
    Fundació Institut de Bioenginyeria de Catalunya
Fund: 195.646,25 €

Characterisation new neurodegeneration suppressors in type 1 myotonic dystrophy (DM1)

  • Dra. Patricia Robledo Montoya
    IMIM - Institut Hospital del Mar d'Investigacions Mèdiques. Barcelona
  • Dr. Manuel Pérez Alonso
    Institut de Recerca Sanitària. València
Fund: 299.936,25 €

Searching new biomarkers and therapeutic targets related to cognitive deficits in early stages of Alzheimer's Disease: Role of AKAP79/150, CPT1C and SSAO/VAP-1 in Ab-mediated AMPAR dysfunction

  • Dr. José Rodriguez Álvarez
    Institut de Neurociències. Universitat Autònoma de Barcelona
Fund: 199.875 €

Role of biomarkers in different clinical presentations of motor neuron disease

  • Dr. Ricardo Rojas Garcia
    Hospital de la Santa Creu i Sant Pau - Institut de Recerca HSCiSP
Fund: 150.625,00 €

Study of genetic frontotemporal dementia in preclinical and initial clinical phases: cognitive profile, structural and functional neuroimaging and biochemical markers

  • Dra. Raquel Sánchez del Valle Díaz
    IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
Fund: 190.181,25 €

Ictal brain SPECT in the premotor phase of Parkinson’s disease

  • Dr. Joan Santamaria Cano
    IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
Fund: 74.875 €

New therapies with stem cells for Duchenne muscular dystrophy

  • Dr. Antonio L. Serrano Sánchez
    Facultat Ciències Salut i Vida - UPF. Barcelona
  • Dr. Francesco Saverio Tedesco
    Cell and Developmental Biology - University College. London
  • Dr. Giulio Cossu
    Centre for Tissue Injury and Repair - University of Manchester (UK)
Fund: 398.825 €

Brain connectomics and metabolic imaging by means of magnetic resonance in the TgF344-AD rat: new focus for the study of Alzheimer’s disease

  • Dra. Guadalupe Soria Rodríguez
    IDIBAPS - Institut d'Investigació Biomèdica August Pi i Sunyer
Fund: 199.988,75 €

Preclinical test of chemical compounds against the toxic effects of mutant huntingtin in mouse models of Huntington’s diseasen

  • Dr. Rafael Vázquez-Manrique
    Hospital Universitari i Politècnic La Fe. València
Fund: 200.000 €

Study of the role of a-synuclein strains in the induction and dissemination of synucleinopathies

  • Dr. Salvador Ventura Zamora
    Institut Biotecnologia i Biomedicina - UAB. Bellaterra
  • Dr. Tiago Outeiro
    University Medical Center Goettingen (Alemanya)
  • Dr. Juan Maria Torres Trillo
    Centro de Investigación en Sanidad Animal - Instituto Nacional de Investigación y Tecnologia Agraria y Alimentaria. Valdeolmos (Madrid)
Fund: 400.000 €

Evaluation of INFOSA-DEM, an innovative informational, educational and social support intervention for informal carers of people with dementia at home. Experimental study

  • Dra. Adelaida Zabalegui Yárnoz
    Hospital Clínic i Provincial de Barcelona - Fundació Clínic per a la Recerca Biomèdica
Fund: 133.751,25 €
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