FUNDED PROJECTS:
DIABETES AND OBESITY

cartell MaratóIn the 2015 Marató, which dealt with diabetes and obesity, 136 projects were presented and these were assessed by 65 scientists specialising in these diseases, according to their quality, methodology and relevance This assessment was managed by the Agency for Health Quality and Assessment of Catalonia, of the Catalan Ministry of Health.
In accordance with the proposal of the scientific Advisory Committee of the Fundació La Marató de TV3, the Board agreed to distribute €8,360,821 to the following 33 research projects of excellence:

Weight control and obesity reduction through diet and physical activity intervention in breast cancer survivors

  • Dr. Antonio Agudo Trigueros
    Institut Català d'Oncologia - IDIBELL Institut d'Investigació Biomèdica de Bellvitge IDIBELL
Fund: 195.666,92 €

Lipotoxicity and microvascular disease: Contribution to myocardial damage in clinical and experimental models of diabetes

  • Dra. Núria Alonso-Pedrol
    IIGTiP Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol
  • Dr. Josep Julve Gil
    IRHSP Institut de Recerca Hospital de la Santa Creu i Sant Pau
Fund: 269.902,50 €

Targeting the genetic causes of diabetes through gene therapy: Therapeutic approaches for MODY

  • Dra. Fàtima Bosch Tubert
    Centre de Biotecnologia Animal i Teràpia Gènica - Universitat Autònoma de Barcelona
  • Dr. Steve Brown
    Medical Research Council – Oxfordshire
  • Dr. Martin Hrabe de Angelis
    Helmholtz Center Munich, German Research - Neuherberg
Fund: 300.000 €

Chrononutrition and chronotype and their relationship with obesity and type II diabetes

  • Dra. Paula Jakszyn
    Institut Català d'Oncologia - IDIBELL Institut d'Investigació Biomèdica de Bellvitge IDIBELL
Fund: 199.862,50 €

Control of systemic and tissue-specific obesity-induced insulin resistance by nuclear receptors

  • Dra. M. del Carmen Caelles Franch
    Facultat de Farmàcia - Universitat de Barcelona
  • Dra. Annabel Valledor Fernández
    Facultat de Biologia - Universitat de Barcelona
  • Dra. Mercedes Ricote Pacheco
    CNIC Centro Nacional de Investigaciones Cardiovasculares Carlos III - Madrid
Fund: 400.000 €

Role of released and exosomial microRNAs, inflammatory and diabetes associated (REx-MIDAs), in endothelial metabolic memory

  • Dr. Antonio Ceriello
    IDIBAPS Institut d'Investigació Biomèdica August Pi i Sunyer
Fund: 199.375 €

Combinatorial gene therapy strategy to target oxidative and endoplasmic reticulum stresses in type 2 diabetic neuropathy

  • Dr. Miguel Chillón Rodríguez
    Institut de Neurociències - Universitat Autònoma de Barcelona
Fund: 199.664,56 €

Polygenic risk scores and type 2 diabetes: Modulation by obesity and dietary intervention in determining diabetes incidence and cardiovascular diseases

  • Dra. Dolores Corella Piquer
    Facultat de Medicina - Universitat de València
Fund: 199.998,28 €

Diabetes Prevention: Translating a feasible and cost-effective lifestyle intervention into primary care to reduce the social burden of type 2 diabetes. The DP-TRANSFERS project

  • Dr. Bernardo Costa Pinel
    IDIAP Institut d'Investigació en Atenció Primària Jordi Gol - Reus
Fund: 74.389,38 €

Encapsulated synthetic cellular circuits to restore glycemic control in type 1 diabetes

  • Dr. Rubén Díaz Naderi
    Hospital Sant Joan de Déu – Esplugues de Llobregat
  • Dr. Francesc Posas Garriga
    PRBB Parc de Recerca Biomèdica de Barcelona - Universitat Pompeu Fabra
  • Dr. Gorka Orive Arroyo
    Facultad de Farmacia - Universidad del Pais Vasco
Fund: 399.980 €

Modeling three-dimensional chromosomal structure in beta cells to identify genetic mechanisms underlying type 2 diabetes

  • Dr. Jorge Ferrer Marrades
    IDIBAPS Institut d'Investigació Biomèdica August Pí i Sunyer
  • Dr. Marc A. Martí-Renom
    Centre Nacional d'Anàlisi Genòmica - CRG Centre de Regulació Genòmica
  • Dr. José Luis Gómez Skarmeta
    Centro Andaluz de Biología de Desarrollo - CSIC Consejo Superior de Investigaciones Científicas
Fund: 350.000 €

Identification of molecular mediators of signalling from intestine to insulin sensitization and the browning of adipose tissue: role of LBP and FGF15/19

  • Dra. Marta Giralt Oms
    Facultat de Biologia - Universitat de Barcelona
  • Dr. José María Moreno Navarrete
    Hospital Dr. Josep Trueta - IDIBGi Institut d'Investigació Biomèdica de Girona
Fund: 299.625 €

Liver glycogen, a novel target to treat diabetes and obesity

  • Dr. Joan J. Guinovart Cirera
    IRBB Institut Recerca Biomèdica de Barcelona
Fund: 200.000 €

Pre-clinical Alzheimer's disease and type 2 diabetes and obesity. Effects of bariatric surgery: a multimodal study

  • Dra. Amanda Jiménez Pineda
    Hospital Clínic i Provincial de Barcelona
  • Dr. Rafael Blesa González
    IRHSP Institut de Recerca Hospital de la Santa Creu i Sant Pau
Fund: 299.937,50 €

The impact of energy metabolism on epigenetic modifications related to the combination of diabetes and obesity

  • Dr. Jorge Joven Maried
    IISPV Institut d’Investigació Sanitària Pere Virgili - Reus
Fund: 199.420 €

Executive function training in childhood obesity: food choice, quality of life and brain connectivity (TOuCH)

  • Dra. María Ángeles Jurado Luque
    Institut de Neurociències - Universitat de Barcelona
Fund: 186.216,25 €

Restricting obesity: anti-S6K1 therapy

  • Dra. Sara Catherine Kozma
    IDIBELL Institut d'Investigació Biomèdical Hospital Univesitari de Bellvitge
Fund: 200.000 €

School-based behavioural intervention to face obesity and promote cardiovascular health among Spanish adolescents: a cluster-randomized controlled trial

  • Dra. Rosa Maria Lamuela Raventós
    Facultat de Farmàcia Universitat de Barcelona - Fundació Bosch i Gimpera
  • Dra. Gloria Santos Beneit
    Foundation for Science, Health and Education Fundación She - Barcelona
  • Dr. Juan Miguel Fernández Alvira
    CNIC Centro Nacional de Investigaciones Cardiovasculares Carlos III - Madrid
Fund: 399.728,75 €

Selective targeting of inflammatory functions of fat-activated macrophages for the treatment of obesity-associated type-2 diabetes

  • Dra. Cristina López Rodríguez
    Facultat de Ciències de la Salut i Vida – Facultat Pompeu Fabra
  • Dr. Ángel Luis Corbi López
    Centro de Investigaciones Biológicas - CSIC Consejo Superior de Investigaciones Científicas
Fund: 300.000 €

Study of new molecular targets in preclinical models of obesity

  • Dra. Elena Martín Garcia
    Laboratori de Neurofarmacologia - Universitat Pompeu Fabra
  • Dra. Mara Dierssen Sotos
    CRG Centre de Regulació Genòmica
  • Dr. Emmanuel Valjent
    Institut de Génomique Fontionnelle INSERM - Montpellier
Fund: 398.646,39 €

Urban environment and childhood obesity in Catalonia (ECHOCAT)

  • Dra. Vrijheid Martine
    Institut de Salut Global de Barcelona
  • Dra. Talita Duarte Sallés
    IDIAP Institut d'Investigació en Atenció Primària Jordi Gol - Reus
Fund: 299.945,75 €

Dietary patterns in weight gain and obesity incidence in children at the ages of 4 and 7 years in a birth cohort in Spain

  • Dra. Eva María Navarrete Muñoz
    CIBER Facultad de Medicina – Universidad Miguel Hernández Alacant
Fund: 41.323,75 €

Relevance of the cluster miR-424(322)/503 in the development of hyperplastic adipose tissue

  • Dr. Francisco José Ortega Delgado
    Hospital Dr. Josep Trueta - IDIBGi Institut d'Investigació Biomèdica de Girona
  • Dr. David Llobet Navas
    IDIBELL Institut d'Investigació Biomèdica de Bellvitge
Fund: 299.875,85 €

Beta cells cis-regulatory networks and type 1 diabetes

  • Dr. Lorenzo Pasquali
    HUGTiP Institut d'Investigació Hospital Universitari Germans Trias i Pujol
Fund: 200.000 €

Lipid droplet overloading promotes pathogenesis and progression of type 2 diabetes: Identifying new therapeutic targets and applying upgraded therapies

  • Dr. Albert Pol Sorolla
    IDIBAPS Institut d'Investigació Biomèdica August Pí i Sunyer
Fund: 199.920 €

Potentiation of mitochondrial activity in adipose tissue as a therapeutic strategy for obesity and type 2 diabetes: Interplay between oxygen sensing and neuregulin signalling*

  • Dr. Wifred Ricart Engel
    Hospital Dr. Josep Trueta - IDIBGi Institut d'Investigació Biomèdica de Girona
  • Dr. Julián Aragonés López
    Instituto de Investigación Sanitaria – Hospital Universitario de La Princesa Madrid
  • Dra. Marta Camps Camprubí
    Facultat de Biologia - Universitat de Barcelona
* The Board agreed at its meeting on 18 May 2017 to extend the funding of this project with €163,303.63 coming from Dr Pablo Sierra’s project, when the investigator and the research centre waived funding. Thus, the project led by Dr Ricart will receive 100% of the funding that was applied for. The difference up to the €200,000 assigned to Dr Serra’s project will be allocated to the Foundation’s goals of research and awareness-raising.
Fund: 230.946,37 €

Carnitine palmitoyltransferase 1-mediated strategies to activate brown fat and reduce food intake to fight against obesity

  • Dra. Dolors Serra Cucurull
    Facultat de Farmàcia - Universitat de Barcelona
  • Dra. Núria Casals Ferré
    Facultat Medicina i Ciències de la Salut - Universitat Internacional de Catalunya
Fund: 250.000 €

Evaluating the responsiveness of type 1 diabetes patients to pMHC class II-based nanomedicines in humanized mice*

  • Dr. Pau Serra Devecchi
    IDIBAPS Institut d'Investigació Biomèdica August Pi i Sunyer IDIBAPS IDIBAPS Consorci Institut d'Investigacions Biomèdiques A. Pi i Sunyer IDIBAPS Barcelona
* The investigator and the research centre of this project have waived funding from the Fundació La Marató de TV3. The Board agreed at its meeting on 18 May 2017 that the sum of money for this project would be used to fund the whole of the project “Regulation of mitochondrial activity as a therapeutic strategy for obesity and type 2 diabetes” coordinated by Dr Wifred Ricart Engel, of the Hospital Dr Josep Trueta - IdIBGi Instituto de Investigación Biomédica de Girona, which could not be funded 100% because of a lack of financial resources. The difference up to €200,000 will be allocated to the Foundation’s goals of research and awareness-raising.
Fund: 200.000 €

Topical administration of GLP-1: a new strategy for treatment of diabetic retinopathy

  • Dr. Rafael Simó Canonge
    VHIR Institut de Recerca Hospital Universitari Vall d'Hebron
Fund: 199.820 €

Prevention and reversion of non-alcoholic fatty liver disease (NAFLD) among obese patients by means of customized nutritional and physical activity intervention

  • Dr. Josep Antoni Tur Marí
    Facultat de Ciències – Universitat de les Illes Balears
Fund: 199.375 €

Analyses of the global kinase activities in adipose tissue to find molecular differences resulting from insulin resistance across different clinical phenotypes from lean to obese and type 2 diabetic patients. Discovery of new targets for therapy

  • Dr. Joan Vendrell Ortega
    Hospital Universitari Joan XXIII - Institut d'Investigació Sanitària Pere Virgili Reus
  • Dr. Lluís Fajas Coll
    Faculté de Biologie et de médecine - Université de Lausanne
Fund: 300.000 €

A new dawn for type 1 diabetes: Combining a nanotherapy to halt autoimmunity with β-cell regeneration

  • Dra. Marta Vives Pi
    HUGTiP Institut d'Investigació Hospital Universitari Germans Trias i Pujol
Fund: 197.797,50 €

Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCT-A) in type I diabetes mellitus

  • Dr. Javier Zarranz Ventura
    Hospital Clínic i Provincial de Barcelona
Fund: 169.403,75 €

Mechanisms responsible for the defective differentiation capacity of adipose-derived stem cells in obesity: Identification of new regulators amenable for the development of innovative therapies

  • Dr. Antonio Zorzano Olarte
    IRBB Institut Recerca Biomèdica de Barcelona
  • Dra. Sonia Fernández Veledo
    Hospital Universitari Joan XXIII - Institut d'Investigació Sanitària Pere Virgili Reus
Fund: 300.000 €
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