FUNDED PROJECTS:
REGENERATION AND TRANSPLANTATION OF ORGAN AND TISSUES

cartell MaratóIn the 2011 Marató, which dealt with regeneration and transplantation of organs and tissues, 209 projects were presented and these were assessed by 105 scientists specialising in these diseases, according to their quality, methodology and relevance This assessment was managed by the Catalan Agency for Health Technology Assessment and Research, of the Catalan Ministry of Health.
In accordance with the proposal of the scientific Advisory Committee of the Fundació La Marató de TV3, the Board agreed to distribute € 8,037,384 to the following 29 research projects of excellence:

Treatment of osteonecrosis of the femoral head using advanced cell therapy and biomaterials in a sheep experimental model

  • Dr. Màrius Aguirre Canyadell
    Institut de Recerca Hospital Universitari Vall d'Hebron
  • Dra. Maria Pau Ginebra Molins
    Escola Tècnica Superior d'Enginyeria Industrial de Barcelona UPC
Fund: 299.951 €

Stimulation of tolerogenic and anti-inflammatory innate immunity as novel cell therapy in transplantation: the role of calcineurin and NFAT5

  • Dr. José Francisco Aramburu Beltrán
    Facultat Ciències Salut i Vida UPF
  • Dra. Susana de la Luna Gargantilla
    Fundació Privada Centre de Regulació Genòmica
  • Dra. Sara Martínez Martínez
    Centro Nacional de Investigaciones Cardiovasculares Carlos III
Fund: 400.000 €

Immunomodulator and anti-inflammatory capacity of the isoform regulating the C4BP(b-) complement: towards the prevention of graft loss in organ transplantation

  • Dr. Josep Maria Aran Perramon
    Institut d'Investigació Biomèdica de Bellvitge
Fund: 199.927 €

Study of the therapeutic potential of transplantation with intestinal stem cells in inflammatory bowel disease

  • Dr. Eduard Batlle Gómez
    Institut Recerca Biomèdica de Barcelona
  • Dra. Azucena Salas Martínez
    Institut d'Investigació Biomèdica August Pi i Sunyer
Fund: 299.375 €

Cell therapy on the surface of the eye: biosubstitution applications and function of adult mesenchymal stem cells for corneal regeneration

  • Dr. Ricardo Pedro Casaroli Marano
    Hospital Clínic i Provincial de Barcelona
  • Dra. Maria P. de Miguel González
    Hospital Universitario La Paz Madrid
Fund: 245.401 €

Regeneration of dopaminergic neurons in Parkinson’s disease through cell-fusion mediated reprogramming

  • Dra. Maria Pia Cosma
    Centre de Regulació Genòmica
  • Dr. Miquel Vila Bover
    Institut de Recerca Hospital Universitari Vall d'Hebron
Fund: 300.000 €

Study of the contribution made by NK cells to chronic rejection of the transplanted kidney in response to HLA specific antibodies, genetic incompatibility and CMV infection

  • Dra. Marta Crespo Barrio
    Institut de Recerca Hospital del Mar
  • Dr. José Miguel López-Botet Arbona
    Facultat Ciències Salut i Vida UPF
  • Dr. Blas Carlos Vilches Ruiz
    Hospital Universitario Puerta de Hierro Majadahonda
Fund: 396.705 €

Analysis of the control mechanism by which Wnt controls the differentiation of mesenchymal stem cells

  • Dra. Mireia Duñach Masjuan
    Facultat de Medicina UAB
  • Dr. Antonio García de Herreros Madueño
    Institut de Recerca Hospital del Mar
Fund: 216.770 €

Annexin A6 is necessary for liver regeneration

  • Dr. Carlos Enrich Bastus
    Institut d'Investigació Biomèdica August Pi i Sunyer
Fund: 200.000 €

Minor histocompatibility antigens as mediators of alloreactivity in human transplantation

  • Dr. David Gallardo Giralt
    Institut Català d'Oncologia IDIBGI
Fund: 195.213 €

Cell therapy with retinal pigment epithelial cells and photoreceptors differentiated from pluripotent stem cells in a rat model of retinitis pigmentosa

  • Dr. Josep García Arumí García
    Hospital Universitari Vall d'Hebron
  • Dra. Anna M. Veiga Lluch
    CMRB Centre Medicina Regenerativa de Barcelona
Fund: 300.000 €

Inflammation as a therapeutic target for improving cardiac repair and regeneration

  • Dr. David García-Dorado García
    Institut de Recerca Hospital Universitari Vall d'Hebron
  • Dra. Alicia García Arroyo
    Centro Nacional de Investigaciones Cardiovasculares Carlos III
Fund: 300.000 €

Development of new strategies for generation of insulin-producing cells from somatic and induced pluripotent stem cells

  • Dra. Rosa Gasa Arnaldich
    Institut d'Investigació Biomèdica August Pi i Sunyer
  • Dra. Sylvia Bedford
    CMRB Centre Medicina Regenerativa de Barcelona
Fund: 299.776 €

Genetic correction and transdifferentiation towards ciliate cells of fibroblasts from human patients with hearing deficiency

  • Dr. Fernando Giráldez Orgaz
    Facultat Ciències Salut i Vida UPF
  • Dr. Thomas Schimmang
    Instituto BiologíaBiología y Genética Molecular Valladolid
Fund: 295.737 €

Reprogramming of embryonic-endothelial cells to haematopoietic stem cells by means of transcription factors

  • Dr. Thomas Graf
    Centre de Regulació Genòmica
Fund: 200.000 €

Silencing immunological costimulation in kidney transplantation

  • Dr. Josep Maria Grinyó Boira
    Hospital Universitari de Bellvitge
Fund: 200.000 €

Generation of induced pluripotent stem cells from patients with genetic disease affecting kidneys: correction and modelling of kidney diseases in vitro

  • Dr. Bernd Kuebler
    Centre Medicina Regenerativa de Barcelona
  • Dr. Luis Fernando Quintana Porras
    Hospital Clínic i Provincial de Barcelona
Fund: 299.697 €

Nanoparticles of cerium oxide as a new therapeutic tool for tissue regeneration in liver diseases

  • Dr. Wladimiro Jiménez Povedano
    Hospital Clínic i Provincial de Barcelona
  • Dr. Víctor Franco Puntes
    Institut Català de Nanotecnologia UAB
Fund: 299.782 €

Biology analysis of immune tolerance systems in organ transplantation

  • Dr. Juan José Lozano Salvatella
    CIBEREHD Central Office Barcelona
  • Dr. Alberto Sánchez Fueyo
    King's College Hospital London
  • Dr. David Torrents Arenales
    Barcelona Supercomputing Center
Fund: 324.500 €

Regeneration of myelin in multiple sclerosis: investigation of novel therapies that contribute to remyelination based on the genetic signature of neural stem cells and pluripotent stem cells

  • Dr. Xavier Montalban Gairin
    Institut de Recerca Hospital Universitari Vall d'Hebron
  • Dr. Mario Notari
    CMRB Centre Medicina Regenerativa de Barcelona
Fund: 300.000 €

Expansion and redifferentiation of pancreatic beta cells cultivated in nanofibres of self-assembling peptides for transplantation of insulin-producing cells in diabetes

  • Dr. Eduard Montanya Mias
    Hospital Universitari de Bellvitge
  • Dr. Carlos Eduardo Semino Margrett
    Institut Químic de Sarrià URL
Fund: 299.221 €

Regenerative medicine for treatment of Fanconi anaemia: generation of disease-free patient-specific iPSC cells capable of differentiation in haematopoietic and platelet progenitors

  • Dra. Núria Montserrat Pulido
    IBEC Institut Bioenginyeria de Catalunya
  • Dr. Juan Antonio Bueren Roncero
    CIEMAT Centro de Investigaciones Energéticas Mediambientales y Tecnológicas
  • Dr. Jordi Surrallés Calonge
    Facultat de Biociències UAB
Fund: 399.860 €

Optimising regeneration and stem cells transplant therapies in degenerative muscular dystrophies.

  • Dra. Pura Muñoz Cánoves
    ICREA Universitat Pompeu Fabra
Fund: 199.986 €

Therapy with mesenchymal stem cells derived from allogenic adipose tissue in a pig model of myocardial infarction: paracrine mechanisms, immunological response and monitoring of short- and long-term functional effects

  • Dra. Montserrat Rigol Muxart
    Institut d'Investigació Biomèdica August Pi i Sunyer
  • Dr. Borja Ibáñez Cabezas
    Centro Nacional de Investigaciones Cardiovasculares Carlos III
  • Dr. Santiago Roura Ferrer
    Institut Investigació en Ciències de la Salut Germans Trias i Pujol
Fund: 399.675 €

Effect of stem cell migration through magnetic fields in recovery from cerebral infarction

  • Dr. Juan Sahuquillo Barris
    Hospital Universitari Vall d'Hebron
  • Dr. José Manuel García Verdugo
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva UV
  • Dr. Luis Martí Bonmatí
    Hospital Universitari i Politècnic La Fe València
Fund: 305.675 €

Development of a protocol for the production of the extracellular matrix from vascular smooth muscle cells of a mouse model of Marfan syndrome to evaluate future therapeutic strategies

  • Dra. Elisabet Sarri Plans
    Facultat de Medicina UB
Fund: 108.750 €

Transplanting type II alveolar cells for treatment of idiopathic pulmonary fibrosis

  • Dra. Anna Serrano Mollar
    Institut Investigacions Biomèdiques de BCN
Fund: 198.758 €

Bone regeneration by dental stem cells

  • Dr. Francesc Ventura Pujol
    Facultat de Medicina CSUB
  • Dr. Corrado Paganelli
    Dental School Brescia
Fund: 252.625 €

Open prospective study of a single intrathecal injection, pilot in phase I/IIa, to evaluate safety and to obtain preliminary results of efficacies of a stem cells transplant

  • Dr. Joan Vidal Samsó
    Institut Guttmann Hospital de Neurorehabilitació
  • Dr. Joan García López
    BST - Banc de Sang i Teixits
Fund: 300.000 €
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