FUNDED PROJECTS:
ALZHEIMER AND OTHER DISEASES OF THE BRAIN

cartell MaratóIn the 2005 Marató, which focused on Alzheimer and other diseases of the brain, 204 projects were presented and these were assessed by 201 scientists specialising in these diseases, according to their quality, methodology and relevance. This assessment was managed by the Catalan Agency for Health Technology Assessment and Research, of the Catalan Ministry of Health.
In accordance with the proposal of the scientific Advisory Committee of the Fundació La Marató de TV3, the Board agreed to distribute € 6,890,426 to the following 35 research projects of excellence:

Development of neuroprotector strategies with BDNF for Huntington's disease

  • Dr. Jordi Alberch Vié
    Facultat de Medicina. Universitat de Barcelona
Fund: 187.500 €

The acetylation of chromatin and the expression of CREB-dependent genes in the pathology of Huntington's disease

  • Dr. Ángel Luis Barco Guerrero
    Institut de Neurociències d'Alacant
Fund: 133.750 €

The role of ictal functional magnetic resonance in locating the epileptogenic area in patients with drug-resistant focal epilepsy

  • Dra. Núria Bargalló Alabart
    Hospital Clínic i Provincial de Barcelona
Fund: 115.135 €

Differential expression of isoforms of alpha-synuclein: a possible marker in peripheral blood of Parkinson disease

  • Dra. Katrin Beyer
    Hospital Universitari Germans Trias i Pujol
Fund: 135.875 €

Identification of genes involved in susceptibility to hyperhomocysteinaemia, a risk factor of cerebral vascular accident and Alzheimer's disease

  • Dr. Francisco Blanco Vaca
    Hospital de la Santa Creu i Sant Pau
Fund: 187.059 €

Evaluation study of management of the ictus patient in primary health care

  • Dr. Carlos Brotons Cuixart
    EAP Sardenya
Fund: 44.733 €

Striatal histamine H3 receptors in the control of motor activity and as a target of Parkinson's disease

  • Dr. Enric I. Canela Campos
    Facultat de Biologia. Universitat de Barcelona
Fund: 136.125 €

Implication of the hypothalamic carnitine palmitoyl transferases 1 (CPT1) in the regulation of hunger

  • Dra. Núria Casals Farré
    Facultat de Ciències de la Salut. Universitat Internacional de Catalunya
Fund: 155.000 €

Mechanisms involved in the development of ischaemic neurological complications in giant cell arteritis

  • Dra. M. Cinta Cid Xutglà
    Hospital Clínic i Provincial de Barcelona
Fund: 170.375 €

Critical disease paralysis: clinical, electrophysiological, biochemical and pathological study

  • Dr. Jaume Coll Cantí
    Hospital Universitari Germans Trias i Pujol
Fund: 57.036 €

Genetic, molecular and cellular bases of migraine and episodic ataxia

  • Dr. Bru Cormand Rifà
    Facultat de Biologia. Universitat de Barcelona
  • Dr. José Manuel Fernández Fernández
    Facultat de Ciències de la Salut i de la Vida. Universitat Pompeu Fabra
Fund: 199.690 €

Implication de Dyrk1A, a candidate gene for Down's syndrome, in Alzheimer type pathology and characterisation of the neuropathological and cognitive effects of cytotoxic protofibrils of peptides derived from natural amyloidal proteins in murine models of Dyrk1A

  • Dra. Mara Dierssen Sotos
    Centre de Regulació Genòmica
  • Dr. José Ramon Naranjo Orovio
    Centro Nacional de Biotecnología. Madrid
  • Dr. Salvador Martínez Pérez
    Institut de Neurociències d'Alacant
Fund: 222.913 €

Excitotoxic mechanisms, neuroinflammatory response and serum factors in human and experimental amyotrophic lateral sclerosis

  • Dr. Josep Enric Esquerda Colell
    Facultat de Medicina. Universitat de Lleida
  • Dr. Joan Serratosa Serda
    Institut d'Investigacions Biomèdiques August Pi i Sunyer
  • Dra. Jerònia Lladó Vich
    Facultat de Ciències. Universitat de les Illes Balears
  • Dr. Carles Solsona Sancho
    Facultat de Medicina CSUB
  • Dr. Ronald William Oppenheim
    Wake Fostest University. Estats Units
Fund: 397.892 €

Study of the preventive mechanisms of non-steroidal anti-inflammatory drugs in Alzheimer's disease: role of the Rho-GTPases

  • Dra. Elena Galea Rodríguez de Velasco
    Institut de Neurociències. Universitat Autònoma de Barcelona
  • Dra. Agustina García Sánchez
    Institut de Biotecnologia i Biomedicina. Universitat Autònoma de Barcelona
  • Dr. Vicente Felipo Orts
    Centro de Investigación Príncipe Felipe. València
Fund: 387.913 €

Countering the progression of Alzheimer's disease: effects of early environmental treatments in triple transgenic 3xTgAD mice

  • Dra. Lydia Giménez Llort
    Institut de Neurociències. Universitat Autònoma de Barcelona
  • Dra. Coral Sanfeliu Pujol
    Institut d'Investigacions Biomèdiques de Barcelona
  • Dr. Björn Johansson
    Karolinska University. Suècia
Fund: 362.131 €

Structural and dynamic characterisation of the process of Abeta aggregation. Study of peptide inhibitors of Abeta aggregation

  • Dr. Ernest Giralt Lledó
    Institut de Recerca Biomèdica de Barcelona
Fund: 157.700 €

Possible neuroprotector potential of treatment with fluorated salicylates in two animal models of multiple sclerosis

  • Dra. Berta González de Mingo
    Facultat de Medicina. Universitat Autònoma de Barcelona
Fund: 185.211 €

Molecular bases of the Lafora type progressive myoclonic epilepsy

  • Dr. Joan J. Guinovart Cirera
    Institut de Recerca Biomèdica de Barcelona
  • Dr. Santiago Rodríguez de Córdoba
    Centro de Investigaciones Biológicas. Madrid
  • Dr. Pascual Sanz Bigorra
    Institut de Biomedicina de València CSIC
Fund: 372.499 €

Molecular and cellular bases and functional implications of the neurogenesis of the adult hippocampus; implications for the pathogenesis of Alzheimer's disease

  • Dr. Juan Carlos Izpisua Belmonte
    Centre de Medicina Regenerativa de Barcelona
  • Dra. Joana Visa Esteve
    Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)
  • Dr. Fred H. Gage
    Salk Institute for Biological Studies. Estats Units
Fund: 399.853 €

Use of cognitive heterogeneity for exploration of the neural bases of slight cognitive deterioration (relatively subtle cognitive impairments) in Parkinson's disease

  • Dr. Jaume Kulisevsky Bojarski
    Hospital de la Santa Creu i Sant Pau
Fund: 187.500 €

Genetic bases of the Chiari type I malformation

  • Dr. Alfons Macaya Ruiz
    Hospital Universitari Vall d'Hebron
Fund: 194.125 €

Study of new therapeutic targets for the development of neuroprotective drugs

  • Dr. Rafael Maldonado López
    Facultat de Ciències de la Salut i de la Vida. Universitat Pompeu Fabra
  • Dr. Fernando Rodríguez de Fonseca
    Hospital Carlos Haya. Màlaga
  • Dr. Emilio Fernández Espejo
    Facultad de Medicina. Sevilla
Fund: 399.165 €

Combined use of neuropsychological, biochemical and neuroimage biomarkers in the risk assessment of dementia in Parkinson's disease

  • Dra. Maria Josefa Martí Domènech
    Hospital Clínic i Provincial de Barcelona
Fund: 105.970 €

Factors associated with knowledge and making of living wills in patients with neurodegenerative pathology

  • Dr. Rafael Martínez Poveda
    Hospital de Mataró
Fund: 20.625 €

Clinical and molecular study of FXTAS syndrome (Fragile X tremors ataxia syndrome)

  • Dra. Montserrat Milà Recasens
    Hospital Clínic i Provincial de Barcelona
Fund: 170.000 €

GRECOS project: genotyping the risk of recurrence of ictus

  • Dr. Joan Montaner Villalonga
    Hospital Universitari Vall d'Hebron
Fund: 198.662 €

Duchenne muscular dystrophy: beneficial effects of fibrinolysis and action mechanisms

  • Dra. Pura Muñoz Cánoves
    Centre de Regulació Genòmica
Fund: 158.110 €

The mouse with accelerated senescence (SAMP8): an experimental model to characterise the first neuronal changes in Alzheimer's disease

  • Dra. Mercè Pallàs Lliberia
    Facultat de Farmàcia. Universitat de Barcelona
  • Dra. Gemma Casadesús Rierola
    Case Western Reserve University. Estats Units
Fund: 199.982 €

The SLC28 genes as new targets for the treatment of ictus and of the neurodegenerative diseases

  • Dr. Marçal Pastor-Anglada
    Facultat de Biologia. Universitat de Barcelona
Fund: 187.500 €

Evaluation of care for ictus in Catalonia following the introduction of an organised and integrated model of care for acute ictus

  • Dr. Gaietà Permanyer Miralda
    Hospital Universitari Vall d'Hebron
Fund: 191.813 €

Plasticity in the sensory-motor cortex induced by musical therapy in patients with cerebrovascular accident

  • Dr. Antoni Rodríguez Fornells
    Facultat de Psicologia. Universitat de Barcelona
  • Dr. Thomas Münte
    Ableitung für Neuropsychology. Alemanya
  • Dr. Carles Grau Fonollosa
    Facultat de Medicina. Universitat de Barcelona
Fund: 360.182 €

Pathogenic mechanisms in the mouse with neuromuscular degeneration (NMD): a model for human SMARD1

  • Dr. Antonio Luis Serrano Sánchez
    Centre de Regulació Genòmica
  • Dra. Lucía Tabares Domínguez
    Facultad de Medicina. Universidad de Sevilla
Fund: 193.625 €

Development and validation of an automatic injection system of a radioactive dose to do ictal SPECT in epilepsy

  • Dr. Francisco Javier Setoain Perego
    Hospital Clínic i Provincial de Barcelona
Fund: 89.357 €

Genetic and environmental factors that influence the phenotype expression of Parkinson's disease caused by mutations in the LRRK2 gen. Clinical and image studies in people without parkinsonism and carriers of the mutation

  • Dr. Eduard Tolosa Sarró
    Hospital Clínic i Provincial de Barcelona
  • Dr. Pau Pastor Muñoz
    Centro para la Investigación Médica Aplicada. Pamplona
Fund: 199.720 €

Environmental conditioning factors of health-related quality of life of patients with advanced institutionalised dementia

  • Dr. Antoni Turon Estrada
    Hospital de Santa Caterina
Fund: 25.700 €
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