FUNDED PROJECTS:
CHRONIC INFLAMMATORY DISEASES

cartell MaratóIn 2002 the Marathon, which was dedicated to chronic inflammatory diseases, received 80 project applications; these were evaluated by 32 scientific specialists around the world who drew up an order of priority depending on the methodological quality and relevance of the project. The assessment was managed by the Catalan Agency for Health Technology Assessment and Research.
In accordance with the proposal from the Advisory Committee of the Fundació La Marató de TV3, the Board agreed to distribute, after paying the costs of the evaluation, € 3,876,669 to the 20 biomedical research projects listed below and used to support research on these diseases. The results were published in the IX Simposium Fundació La Marató de TV3 which took place in 2008.

Therapeutic effect of probiotics in active Crohnís disease and their action mechanism. Randomised, double-blind, prospective pilot study, comparing enteral nutrition plus a symbiotic composition versus enteral nutrition plus placebo during four weeks

  • Dr. Doroteo Acero Fernández
    Hospital Universitari Doctor Josep Trueta. Girona
  • Dr. Jesús García Gil
    Facultat de Ciències UdG
  • Dr. Richard Day
    St. Mark's Hospital. Academic Institute. London
Fund: 251.637 €

Regulation of platelet activator factor levels as an etiologic factor in inflammatory intestinal disease

  • Dr. Juan Aguilar Piera
    Facultat de Farmàcia UB
Fund: 141.950 €

Design and synthesis of peptides and peptidomimetics as therapeutic agents with anti-inflammatory ability.

  • Dr. Fernando Albericio Palomera
    Institut de Recerca Biomèdica de Barcelona
  • Dr. Enrique Pérez Payá
    Institut d'Investigacions Citològiques. València
Fund: 179.750 €

Belgium Search for new therapeutic strategies for chronic autoimmune arthritis based on steroid transrepression

  • Dra. Anna Bigas Salvans
    Institut de Recerca Oncològica
  • Dr. Guy Haegeman
    University of Gent. Belgium
  • Dr. Dirk Elewaut
    Gent University Hospital. Belgium
Fund: 360.000 €

Action mechanism of antimicrobial peptides y proteins of the immune system. Involvement in the pathogeny of inflammatory intestinal diseases

  • Dra. Ester Boix Borràs
    Facultat de Ciències UAB
Fund: 101.814 €

Glucocorticoid interference mechanisms with the MAPK routes as a basis for their anti-inflammatory action. Increasing the anti-inflammatory action of current glucocorticoids.

  • Dra. M. del Carmen Caelles Franch
    Facultat de Farmàcia UB
Fund: 180.000 €

Medico-legal study of the suitability of disability cover in patients with Crohnís disease. Analysis of the legal precedents, design of a disability score, and evaluation of the current degree of socio-health cover

  • Dr. Xavier Calvet Calvo
    Hospital de Sabadell
Fund: 125.000 €

Usefulness of evaluating apoptosis of mononuclear cells of the intestinal mucosa of patients with inflammatory intestinal disease to predict the appearance of refractoriness to steroids. Relationship with the activation of transcription factor NFkB and cytokine transcription

  • Dra. Maria Esteve Comas
    Hospital Mútua de Terrassa
  • Dr. Josep Mañé Almero
    Hospital Universitari Germans Trias i Pujol
Fund: 149.825 €

Minor forms of microscopic colitis: definition based on objective histological criteria and valuation of incidence, clinical characteristics and response to treatment.

  • Dr. Fernando Fernández Bañares
    Hospital Mútua de Terrassa
Fund: 24.662 €

New gene therapy strategies for the treatment of inflammatory intestinal disease: silencing of TNF-alpha expression and overexpression of interleukin-10

  • Dr. Miquel Àngel Gassull Duro
    Hospital Universitari Germans Trias i Pujol
  • Dra. Ester Fernández Gimeno
    Facultat de Veterinària UAB
  • Dr. Miguel Chillón Rodríguez
    Centre de Biotecnologia Animal i Teràpia Gènica UAB
  • Dr. José Carlos Perales Losa
    Facultat de Medicina UB
Fund: 359.744 €

Identification of signalling proteins of glucocorticoid-induced apoptosis as targets for the development of anti-inflammatory pharmaceutical products

  • Dr. Gabriel Gil Gómez
    Institut Municipal d'Investigació Mèdica
Fund: 180.000 €

Regulation and functional role of transcription factors NFAT5 and NFATC in the inflammatory response: in vivo and in vitro study

  • Dra. Cristina López Rodríguez
    Parc de Recerca Biomèdica de Barcelona
  • Dr. José Francisco Aramburu Beltrán
    Facultat de Ciències de la Salut i de la Vida UPF
  • Dr. Juan Miguel Redondo Moya
    Centro Nacional de Investigaciones Cardiovasculares Carlos III
Fund: 360.000 €

Childhood inflammatory arthritis: prospective study of its incidence and prevalence in Catalonia

  • Dra. Consuelo Modesto Caballero
    Hospital Universitari Vall d'Hebron
Fund: 111.384 €

Double-blind, randomised, placebo-controlled, multicentre, phase III, pilot clinical trial on the usefulness of associating Metronidazole with Azathioprine in the prevention of post-surgical recurrence in Crohnís disease

  • Dra. Rosa Mª Morillas Cunill
    Hospital Universitari Germans Trias i Pujol
Fund: 74.880 €

Quality of life related to health in patients with rheumatoid arthritis in Catalonia

  • Dra. Montserrat Nuñez Juárez
    Hospital Clínic i Provincial de Barcelona
Fund: 65.000 €

Functional characterisation of the calcipressin 1-calcineurin interaction and application to the development of new therapeutic routes for the treatment of Crohnís disease.

  • Dra. Mercè Pérez Riba
    Institut de Recerca Oncològica
  • Dr. Angel Messeguer Peypoch
    Institut d'Investigacions Químiques i Ambientals de Barcelona
Fund: 180.000 €

Effects of nonsteroidal anti-inflammatories on the course of inflammatory intestinal disease. Study of the susceptibility mechanisms and development of diagnostic tools

  • Dr. Josep Maria Piqué Badia
    Hospital Clínic i Provincial de Barcelona
  • Dr. Raúl Méndez de la Iglesia
    Centre de Regulació Genòmica
  • Dr. Àngel Lanas Arbeloa
    Hospital Clínico Universitario Lozano Blesa. Zaragoza
Fund: 358.534 €

Genetic analysis of the role of MAPK p38 in inflammation

  • Dr. Francesc Posas Garriga
    Institut de Recerca Biomèdica de Barcelona
  • Dr. Ángel R. Nebreda
    Centro Nacional de Investigacions Oncológicas. Madrid
  • Dr. Manolis Pasparakis
    European Molecular Biology Laboratory. Monterotondo
Fund: 131.000 €

Gene expression profile in inflammatory intestinal disease

  • Dr. Adolfo Río Fernández
    Hospital Universitari Germans Trias i Pujol
  • Dr. Antonio Suárez Garcia
    Facultad de Farmacia. Universidad de Granada
  • Dr. German Soriano Pastor
    Hospital de la Santa Creu i Sant Pau
Fund: 296.640 €

Antibodies against citrulline peptides in short-evolution rheumatoid arthritis: diagnostic and prognostic significance

  • Dr. Raimon Sanmarti Sala
    Hospital Clínic i Provincial de Barcelona
  • Dra. Isabel Haro Villar
    Institut d'Investigacions Químiques i Ambientals de Barcelona
  • Dr. Alejandro Balsa Criado
    Sociedad Española de Reumatologia
Fund: 244.080 €