FUNDED PROJECTS:
TRANSPLANTS

cartell MaratóFollowing the 1999 edition, dedicated to transplants, the sum of € 3,885,668 was distributed among 58 biomedical research projects. The results were published in the VI Simposium Fundació La Marató de TV3, which took place in 2005.
Below is a list of the projects financed by La Marató in 1999. Those that led to the production of scientific literature are underlined.

The role of NFATs and calcineurine in immune response: Implications in the effectiveness and toxicity of immunosuppressant approaches

  • Dr. José Francisco Aramburu Beltrán
    Facultat de Ciències de la Salut i de la Vida. Universitat Pompeu Fabra
Fund: 65.333 €

Cardiac rejection: Bases for bloodless detection of possible processes involved in the myocytic lesion. Characterization of the apoptotic system. Clinical implications and possible repercussions in handling and stratifying risk for transplant patients

  • Dr. Manel Ballester Rodés
    Facultat de Medicina. Universitat de Lleida
  • Dr. Joan X. Comella Carnicé
    Facultat de Medicina. Universitat de Lleida
  • Dr. Ignasi Carrió Gasset
    Hospital de la Santa Creu i Sant Pau
  • Dr. Joan Castell Conesa
    Centre PET Barcelona. Fundació CETIR
Fund: 141.239 €

Chimerism and tolerance: Applications in gene therapy and transplants.

  • Dr. Jordi Barquinero Máñez
    Hospitals Vall d'Hebron
Fund: 52.625 €

Preventing the development of acute pulmonary lesion due to artificial respiration in lung donors. The modulating effect of vasodilators and the protective effect of partial liquid respiration in an experimental model

  • Dr. Lluís Blanch Torra
    Hospital de Sabadell. Consorci Hospitalari del Parc Taulí
Fund: 36.954 €

Comparative study on the effects and mechanisms by which the immunosuppressants cyclosporine A, tacrolimus and mycophenolate mofetil act on the development of hyperlipemia, hyperhomocysteinemia, common arteriosclerosis and vasculopathy following transplant

  • Dr. Francisco Blanco Vaca
    Hospital de la Santa Creu i Sant Pau
Fund: 44.625 €

Determining the phosphatase activity of calcineurine in T lymphocytes as biological marker for the level of immunodepression achieved in patients treated with tacrolimus or cyclosporine

  • Dra. Mercè Brunet Serra
    Hospital Clínic i Provincial de Barcelona
Fund: 28.398 €

Study of an alternate therapy for preventing neurotoxic effects from cyclosporine A in organ transplants

  • Dr. Antoni Camins Espuny
    Facultat de Farmàcia. Universitat de Barcelona
Fund: 21.724 €

Study of endothelial dysfunction in kidney transplants. Role of immunosuppressant treatment

  • Dr. Josep M. Campistol Plana
    Hospital Clínic i Provincial de Barcelona
Fund: 28.925 €

Pathogenic mechanisms of the lymphoproliferative syndromes associated with solid organ transplants and their possible value in predicting patient evolution

  • Dr. Elías Campo Güerri
    Hospital Clínic i Provincial de Barcelona
Fund: 108.939 €

Liver transplants and quality of life. Design of a specific quality of life questionnaire applicable in Catalonia

  • Dra. Teresa Casanovas Taltavull
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 59.506 €

Functional and molecular characterization of the ACII (Activator of Class II) transcription factor in regulating the expression of molecules of the main complex of Class II histocompatibility

  • Dr. Antonio Celada Cotarelo
    Facultat de Biologia. Fundació August Pi i Sunyer
Fund: 80.866 €

Initial endothelial dysfunction as prediction of the appearance of coronary vasculopathy during follow-up of patients undergoing heart transplants

  • Dr. Àngel Ramon Cequier Fillat
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 93.774 €

Study of the ischemia reperfusion injury in liver transplants in humans and pigs. Evaluation of portal administration of Prostaglandin E1 during the revascularization phase of liver grafts

  • Dr. Alfredo Escartín Arias
    Hospitals Vall d'Hebron
Fund: 88.078 €

Study of the molecule of the 2B4 leucocyte membrane as a new therapeutic target for xenotransplants

  • Dr. Pablo Engel Rocamora
    Facultat de Medicina. Fundació Clínic per a la Recerca Biomèdica
Fund: 54.643 €

Cellular and molecular analysis of liver regeneration following hepatectomy. Implications during liver transplant from living donors

  • Dr. Carlos Enrich Bastus
    Facultat de Medicina. Fundació Clínic per a la Recerca Biomèdica
Fund: 84.744 €

Prospective evaluation of the CD4+ T-lymphocyte response specific to the hepatitis C virus (VCH) in VCH-positive liver transplant recipients. Reconstitution of the specific immune response

  • Dr. Joan Ignasi Esteban Mur
    Hospitals Vall d'Hebron
Fund: 58.388 €

The role of vitamin D in vascular pathology associated with kidney transplants

  • Dra. Elvira Dolores Fernández Giráldez
    Facultat de Medicina. Universitat de Lleida
Fund: 48.418 €

Molecular physiopathology of arterial hypertension caused by calcineurine inhibitors. Study of the gene and protein expression of renal sodium carriers in an experimental model of arterial hypertension caused by cyclosporine

  • Dra. Patricia Fernández-Llama
    Hospital Clínic i Provincial de Barcelona / Fundació Puigvert
Fund: 54.015 €

Study of the prognostic value of the expression of modulating factors of the G1 phase in hepatic carcinomas and their usefulness in selecting liver transplant recipients

  • Dr. Joan Figueras Felip
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 39.593 €

Study of neutralizing antibodies against the hepatitis C virus (VHC) in positive antiVHC immunoglobulin preparations: usefulness in preventing infection due to VHC in liver transplants

  • Dr. Xavier Forns Bernhardt
    Hospital Clínic i Provincial de Barcelona
Fund: 99.678 €

Study of the intrahepatic oxygen flow and consumption as a marker for ischemia injuries of the liver during hepatectomy in living donors

  • Dr. Josep Fuster Obregon
    Hospital Clínic i Provincial de Barcelona
Fund: 38.505 €

Influence of hemopoietic microchimerism in the development of graft rejection in kidney and heart transplants. Establishing a scale of risk of rejection

  • Dr. David Gallardo Giralt
    Hospital Duran i Reynals
Fund: 28.187 €

Experimental liver transplant in pigs. The effect of modifying normothermal recirculatory features on the viability of liver grafting

  • Dr. Juan Carlos García-Valdecasas Salgado
    Hospital Clínic i Provincial de Barcelona
Fund: 88.848 €

Evaluation of immunomodulation by adenovirus gene therapy as a therapeutic strategy in experimental liver and intestine transplants

  • Dr. Miquel Àngel Gassull Duro
    Hospital Universitari Germans Trias i Pujol
  • Dr. Kimberlay M. Olthoff
    University Hospital. Pennsylvania
  • Dra. Ester Fernández Gimeno
    Facultat de Veterinària. Universitat Autònoma de Barcelona
Fund: 148.829 €

Modulating the apoptosis as a mechanism for mediating the preserving action of the transplanted organ against immunosuppressive drugs

  • Dr. Gabriel Gil Gómez
    Institut Municipal d'Investigació Mèdica
Fund: 45.720 €

Terlipressin in treating patients with cirrhosis of the liver and hepatorenal syndrome who are candidates for liver transplant. Effects on survival and kidney function. Randomized, prospective study

  • Dr. Pere Ginés Gibert
    Hospital Clínic i Provincial de Barcelona
Fund: 80.333 €

Remote-control of the graft and organ lesion associated with the ischemia-reperfusion syndrome in liver transplants

  • Dr. Luis Grande Posa
    Hospital Clínic i Provincial de Barcelona
Fund: 44.872 €

Effects of immunosuppressant treatment with rapamycine, tacrolimus or cyclosporine on vascular graft disease in a model of arterial allografting in pigs

  • Dra. M. Magdalena Heras Fortuny
    Hospital Clínic i Provincial de Barcelona
Fund: 69.201 €

New therapeutic strategies for preserving tissue and preventing rejection: gene transfer of the Akt kinase serine/treonine protein

  • Dr. Wladimiro Jiménez Povedano
    Hospital Clínic i Provincial de Barcelona
Fund: 55.443 €

Analysis of cost-effectiveness of adjuvant treatment of hepatocellular carcinoma on the waiting list for liver transplants

  • Dr. Josep M. Llovet Bayer
    Hospital Clínic i Provincial de Barcelona
Fund: 40.978 €

Tissue engineering of the allogenic endothelium: Regulating immunological, inflammatory and atherogenic mechanisms associated with chronic rejection

  • Dr. Ramon Llull Cerdà
    Institut Municipal d'Investigació Mèdica
Fund: 120.162 €

Analysis of the function of receptors associated with NK cells (NKR) in response to infection due to cytomegalovirus

  • Dr. José Miguel López-Botet Arbona
    Facultat de Ciències de la Salut i de la Vida. Universitat Pompeu Fabra
Fund: 48.403 €

Study of the immunological situation of liver transplant recipients by means of functional and immunophenotypical characterization of the mononuclear cells of peripheral blood stimulated by doner antigens

  • Dr. Carles Margarit Creixell
    Hospitals Vall d'Hebron
Fund: 68.392 €

Participation of nitric oxide (NO) in the detection of T lymphocytes specific to transplant antigens in different presentation models

  • Dr. Jaume Martorell Pons
    Hospital Clínic i Provincial de Barcelona
Fund: 87.579 €

Chronic nephrotoxicity due to CsA in patients undergoing transplant. Molecular basis and implication of the codifying gene in Kidneyandrogen Regulated Protein

  • Dra. Anna Meseguer Navarro
    Hospitals Vall d'Hebron
  • Dr. Emilio Itarte Fresquet
    Facultat de Ciències. Universitat Autònoma de Barcelona
  • Dr. Francisco Javier Gómez Pérez
    Centro de Biologia Molecular y Celular. Universidad Miguel Hernández. Alacant
Fund: 175.955 €

Role of the uPA/uPAR and VEGF systems in implantation and neovasculogenesis of skin grafts: Importance in curing burns and ulcers of the skin

  • Dra. Pura Muñoz Cánoves
    Institut de Recerca Oncològica / Centre de Regulació Genòmica
Fund: 39.672 €

Hepatocellular support by means of orthotopic and heterotopic partial liver transplant in an experimental model of liver failure. Analysis of the differences in regeneration of the native liver

  • Dr. Josep Enric Murio Pujol
    Hospitals Vall d'Hebron
Fund: 35.234 €

Cell polarization and migration of dentritic cells: Regulation by kinase proteins of the mammalian-Par1 family (mammPar1)

  • Dr. Estanis Navarro Gómez
    Institut de Recerca Oncològica
Fund: 51.070 €

Clinical and experimental study of the mechanisms of fibrogenesis in the etiopathogeny of chronic nephropathy in kidney grafting. New therapeutic perspectives

  • Dr. Federico Oppenheimer Salinas
    Hospital Clínic i Provincial de Barcelona
Fund: 91.920 €

Effects of kidney transplant on quality of life and psychiatric morbidity

  • Dr. Joan de Pablo Rabassó
    Hospital Clínic i Provincial de Barcelona
Fund: 7.852 €

Evaluation of a new inhibitor of calcineurine, DSCR1, as an immunosuppressant agent

  • Dra. Mercè Pérez Riba
    Institut de Recerca Oncològica
Fund: 59.717 €

Prodigiosine, a new immunosuppressant. Biochemical characterization of the apoptotic system induced by this drug in cellular lines and in T and B lymphocytes

  • Dr. Ricardo Enrique Pérez Tomás
    Facultat de Medicina. Fundació August Pi i Sunyer
Fund: 43.388 €

Preventing acute rejection by means of pig anti-p-selectine blocker antibodies in a xenotransplant model

  • Dra. Maria Pilar Pizcueta
    Lalanza Hospital Clínic i Provincial de Barcelona
Fund: 33.125 €

Heart transplant. Study of rejection markers and physiological and molecular alterations in the transplanted heart; clinical and therapeutic applications

  • Dr. José Luis Pomar Moya-Prats
    Hospital Clínic i Provincial de Barcelona
Fund: 93.542 €

Using real time PCR to typify different MHC loci in the interest of organ transplants

  • Dr. Ricardo Pujol Borrell
    Hospital Universitari Germans Trias i Pujol
  • Dra. Anna Ribera Crusafont
    Centre de Transfusió i Banc de Teixits. Hospitals Vall d'Hebron
  • Dra. Dolores Jaraquemada Pérez de Guzmán
    Institut de Biologia Fonamental Vicent Villar Palasí
Fund: 185.532 €

Strategies for transplanting differentiated pancreatic cells derived from pancreatic and biliary epithelia and ES cells

  • Dr. Francisco X. Real Arribas
    Institut Municipal d'Investigació Mèdica
  • Dr. Senén Vilaró Coma
    Facultat de Biologia. Universitat de Barcelona
  • Dr. Pierre Savatier
    Lab. de Biologie Molléculaire et Cellulaire. Lyon
Fund: 204.447 €

Hepatic fibrosis and fibrosis serum and tissue markers in relapse of infection due to hepatitis C virus in liver transplants

  • Dr. Antoni Rimola Castellà
    Hospital Clínic i Provincial de Barcelona
Fund: 68.185 €

Effect of modulating angiogenesis in chronic vasculopathy in grafts

  • Dra. Eulàlia Roig Minguell
    Hospital Clínic i Provincial de Barcelona
Fund: 89.514 €

Strategies in gene therapy and preconditioning in liver transplant

  • Dr. Joan Roselló Catafau
    Institut d'Investigacions Biomèdiques de Barcelona
Fund: 80.586 €

Importance in the order of vascular unclamping in graft reperfusion in orthotopic liver transplant: Comparative study

  • Dr. Antoni Sabaté Pes
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 11.074 €

Coinfection due to human immunodeficiency virus in patients with chronic hepatopathy. Implications for handling potential candidates for liver transplant (TH) and later complications

  • Dr. Miguel Santín Cerezales
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 42.281 €

Evaluation of molecular mediators of chronic nephropathy of kidney transplant in protocol biopsies

  • Dr. Daniel Serón Micas
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 60.402 €

Gene therapy for preventing rejection in an experimental model of kidney allotransplant. Using numbing molecules to block the costimulating signal CD40-CD40L

  • Dr. Joan Torras Ambros
    Ciutat Sanitària i Universitària de Bellvitge
  • Dr. Josep Maria Aran Perramon
    Institut de Recerca Oncològica
Fund: 40.520 €

Evaluation of the direct cost that can be attributed to heart, liver and kidney transplants in Catalonia

  • Dr. Antoni Trilla Garcia
    Hospital Clínic i Provincial de Barcelona
Fund: 9.956 €

The role of homeostasis of cerebrospinal fluid in developing neurological lesions associated with liver transplant

  • Dr. Víctor Vargas Blasco
    Hospitals Vall d'Hebron
Fund: 36.583 €

Blockage and sequestrum of p27 induced by Myc as a factor limiting the immunosuppressant Rapamycine

  • Dr. Jordi Vives Puiggros
    Hospital Clínic i Provincial de Barcelona
Fund: 60.961 €

Controlled prospective study on the effectiveness of administering immunosuppressants without corticoids in liver transplants

  • Dr. F. Xavier Xiol Quingles
    Ciutat Sanitària i Universitària de Bellvitge
Fund: 21.636 €

Study of the prediction value of genetic polymorphisms of the interleukins IL-10, IL-6, IL-2, IL-4r, TNFalfa and IFNlambda, as markers for acute and chronic rejection in kidney transplants

  • Dr. Jordi Yagüe Ribes
    Hospital Clínic i Provincial de Barcelona
Fund: 86.596 €
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